Isolation and evaluation of the cytotoxic properties of peroxisomicine isomers from Karwinskia parvifolia
نویسندگان
چکیده
A new compound with a peroxisomicine (dimeric hydroxyanthracenone type) structure was isolated from Karwinskia parvifolia and denominated peroxisomicine A4 (PA4). The stereochemistry of the stereogenic centers of this compound and the previously isolated peroxisomicine A3 (PA3, 3) was elucidated using CD, 13 C NMR and 1 H NMR spectra. Four peroxisomicine stereoisomers were cytotoxic to Chang and HepG2 Liver cells. Only peroxisomicine A1 (PA1, 1) and A3 (PA3, 3) showed selective toxicity. Since 1 and 3 are epimers at C-3’ the cytotoxicity results suggest that the stereochemistry at this site may be involved in the cytotoxic properties of these compounds.
منابع مشابه
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